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of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved signaltransduction pathways

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 225-228 doi: 10.1007/s11684-010-0003-z

Abstract: is to study the effect of bradykinin (BK) on bradykinin-B2 receptor as well as the possible involved signaltransduction pathways in cultured rat aortic vascular smooth muscle cells (VSMCs).Apigenin, PD98059, Akt inhibitor, and LY294002 inhibited up-regulation of B2 receptor induced by BK. (3) Signaltransduction pathways of MAPK and PI3K were involved in the up-regulation of B2 receptor by BK mediation

Keywords： bradykinin     vascular smooth muscle cells     signal transduction pathways    

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CHARACTERISTICS OF HERBIVORY/WOUND-ELICITED ELECTRICAL SIGNAL TRANSDUCTION IN TOMATO

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: /i> has been characterized but the characteristics of electrical signal transduction in responsetransduction.Leaflet wounding also activated electrical signal transduction and jasmonic acid (JA) signaling withinThis work reveals the nature of electrical signal transduction in tomato and emphasizes the key rolesof GLR3.3 and GLR3.5 in electrical signal transduction and JA signaling activation.

Keywords： electrical signal / glutamate receptor-like / herbivory / jasmonic acid / tomato    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract: could regulate distinct aspects of neural signal transduction and suggest that the coordinated actionssignal pathway in the developing brain.

Keywords： signal transduction     neurogenic disease    

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Effect of decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-induced

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 363-367 doi: 10.1007/s11684-009-0064-z

Abstract: investigate the effects of (枳黄) decoction on CD14 expression in the lipopolysaccharide signaltransduction pathway of alcohol-induced liver disease in rats.decoction can significantly reduce CD14 expression in the lipopolysaccharide signal transduction pathway

Keywords： liver disease     alcohol     Zhihuang decoction     CD14     signal transduction    

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Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition

Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 311-319 doi: 10.1007/s11684-016-0460-0

Abstract:

We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tail in integrin αIIbβ3 bidirectional signaling using a trans-dominant inhibition model. Chimeric Tac-β3 proteins (i.e., Tac-β3, Tac-β3D741, Tac-β3D747, Tac-β3D754, Tac-β3D759, and Tac-β3DNITY) consisting of the extracellular and transmembrane domains of human IL-2 receptor (Tac) and the human integrin β3 cytoplasmic domain were stably expressed in the 123 CHO cells harboring human glycoprotein Ib-IX and wild-type integrin αIIbβ3. The different cells were assayed for stable adhesion and spreading on immobilized fibrinogen, and for binding soluble fibrinogen representing outside-in and inside-out signaling events, respectively. The chimeric protein Tac-β3 inhibited, and Tac-β3DNITY partially attenuated stable adhesion and spreading. Tac-β3, Tac-β3D759, Tac-β3DNITY, and Tac-β3D754, but not Tac-β3D747 or Tac-β3D741, impaired the soluble fibrinogen binding. Results indicated that the bidirectional signaling was significantly inhibited by Tac-β3 and Tac-β3DNITY, albeit to a much lesser extent. Moreover, only inside-out signaling was impaired in the 123/Tac-β3D759 and 123/Tac-β3D754 cells in contrast to an intact bidirectional signaling in the 123/Tac-β3D747 and 123/Tac-β3D741 cells. In conclusion, the calpain cleavage of integrin β3 resulted in the regulatory effects on signaling by interrupting its interaction with cytoplasmic proteins rather than altering its conformation, and may thus regulate platelet function.

Keywords： integrin β3     signal transduction     trans-dominant inhibition model    

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Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 33-39 doi: 10.1007/s11684-011-0114-1

Abstract: migration of MSCs into the injured tissue are still not fully understood, although multiple signaling pathwaysThis review will briefly summarize the regulatory facors and signaling transduction pathways involved

Keywords： mesenchymal stem cells     migration     molecular mechanisms     signaling pathway    

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Talin and kindlin: the one-two punch in integrin activation

Feng Ye, Adam K. Snider, Mark H. Ginsberg

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 6-16 doi: 10.1007/s11684-014-0317-3

Abstract:

Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important for development, immune response, hemostasis and wound healing. Integrins pass trans-membrane signals bidirectionally through their regulated affinities for extracellular ligands and intracellular signaling molecules. Such bidirectional signaling by integrins is enabled by the conformational changes that are often linked among extracellular, transmembrane and cytoplasmic domains. Here, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipid and kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helps us understand integrin-related diseases.

Keywords： signal transduction     transmembrane domain     nanodisc     integrin     talin     kindling     cell adhesion    

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Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 431-436 doi: 10.1007/s11684-009-0088-4

Abstract: The effects of tanshinone II A on cell signal transduction system protein kinase B in rats with myocardial

Keywords： tanshinone II A     myocardial hypertrophy     rat     protein kinase B     abdominal aorta coarctation    

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Neural networks modeling signal responses and taxol production of cultured Taxus chinensis cells induced

GONG Yanwen, REN Defeng, YUAN Yingjin

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 2,   Pages 118-122 doi: 10.1007/s11705-007-0022-8

Abstract: Quantitatively describing the signal transduction process is important for understanding the mechanismof signal regulation in cells, and thus, poses both a challenge and an opportunity for chemical andAn artificial neural network (ANN), in which we took the signal molecules as neural nodes, was constructedThe robustness of AOS trajectories indicated that signal regulation in vivo was an integral feedback

Keywords： transduction     chinensis     feedback     environmental     generation    

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Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 46-53 doi: 10.1007/s11684-010-0010-0

Abstract: Mitogen-activated protein kinase (MAPK) signaling pathway, one of the most important signaling pathways

Keywords： mitogen-activated protein kinase     drug target     inhibitor     signal transduction     disease    

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Thermodynamic analysis of reaction pathways and equilibrium yields for catalytic pyrolysis of naphtha

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 12,   Pages 1700-1712 doi: 10.1007/s11705-022-2207-6

Abstract: Herein, for a better catalyst design and operation parameters optimization, the reaction pathways andThe results revealed that the thermodynamically favorable reaction pathways for n/iso-paraffinsand cyclo-paraffins were the protolytic and hydrogen transfer cracking pathways, respectively.results are thus useful as a direction for future catalyst improvements, facilitating superior reaction pathways

Keywords： naphtha     catalytic pyrolysis     reaction pathway     equilibrium yield    

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Seasonal variations of transport pathways andpotential sources of PM

Yuan Chen, Shaodong Xie, Bin Luo

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 1, doi: 10.1007/s11783-018-1009-z

Abstract: Seasonal pattern of transport pathways and potential sourcesof PM in Chengdu during 2012–2013were investigatedwith no specific source direction and relativelyhigh PM loadings (>80 mg·m ) appearedas important pathwaysThese short pathways indicatedthat emissions from both local and surrounding regions of Chengducontributed

Keywords： Transport pathway     Backwardtrajectory     Clustering analysis     Potential source     Chengdu    

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ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 3,   Pages 316-332 doi: 10.15302/J-FASE-2022441

Abstract:

● The Green Revolution broadened the trade-off between yield and nitrogen-use efficiency.

Keywords： Nitrogen     root system architecture     phytohormone     crosstalk     nitrogen-use efficiency     breeding strategy    

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PICRUSt2 functionally predicts organic compounds degradation and sulfate reduction pathways in an acidogenic

Frontiers of Environmental Science & Engineering doi: 10.1007/s11783-021-1481-8

Abstract: comprehensive insights into the influences of sulfate on performance, microbial community and metabolic pathways

Keywords： Acidogenic phase reactor     High-sulfate wastewater     Sulfate reduction     Acidogenic fermentation     PICRUSt2    

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Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer

Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 247-253 doi: 10.1007/s11684-010-0027-4

Abstract: In order to find metastasis-related genes and abnormal signal transduction pathway of high-invasive gastricSubsequently, from the preliminary screened genes, molecular pathways possibly impacting liver metastasisFunctional analysis of differentially expressed genes revealed that a variety of biological pathways,We conclude that data mining allows to quickly identify a series of special signal transduction pathways

Keywords： gastric carcinoma     metastasis     signal transduction     gene chips    

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Title Author Date Type Operation

of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved signaltransduction pathways

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Journal Article

CHARACTERISTICS OF HERBIVORY/WOUND-ELICITED ELECTRICAL SIGNAL TRANSDUCTION IN TOMATO

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Effect of decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-induced

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Journal Article

Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition

Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi

Journal Article

Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction

Li LI, Jianxin JIANG

Journal Article

Talin and kindlin: the one-two punch in integrin activation

Feng Ye, Adam K. Snider, Mark H. Ginsberg

Journal Article

Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Journal Article

Neural networks modeling signal responses and taxol production of cultured Taxus chinensis cells induced

GONG Yanwen, REN Defeng, YUAN Yingjin

Journal Article

Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Journal Article

Thermodynamic analysis of reaction pathways and equilibrium yields for catalytic pyrolysis of naphtha

Journal Article

Seasonal variations of transport pathways andpotential sources of PM

Yuan Chen, Shaodong Xie, Bin Luo

Journal Article

ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

Journal Article

PICRUSt2 functionally predicts organic compounds degradation and sulfate reduction pathways in an acidogenic

Journal Article

Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer

Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,

Journal Article